The Covid-19 pandemic has reinforced the value of robust, policy-relevant research to inform decision-making and heightened the need for evidence-informed responses to address worsening inequalities. While international development research has the potential to contribute to a more equitable world, research funders grapple with how to ensure that their support best enables researchers to respond to evolving evidence demands and influence policy and practice. This article reflects on lessons emerging from one of the International Development Research Centre’s (IDRC) rapid-response initiatives and highlights the ongoing experiences of our research partners in influencing policy to address the socioeconomic impacts of the pandemic. We conclude that flexibility of funding, promoting Southern leadership and embedded partnerships, and ongoing support for amplification of research results help to ensure that research is positioned for impact amid constantly evolving priorities. This has implications for research funding practices and underlines the importance of addressing inequities in access to research funding.