Globally, millions of children are living without parental care. Families experience multiple challenges that lead to family–child separation, with financial hardship a common theme. The integration of interventions to strengthen families socially, emotionally, and economically is therefore a priority, but requires knowing which combination(s) of interventions might work for which households. This article reflects on an ongoing evaluation of two projects in Uganda that implemented integrated family and economic strengthening interventions with families at risk of a child being separated and those where a separated child was reunited. We discuss how the practical realities of integrated programming influence research design options and our attempts to mitigate the potential limitations of a non‑experimental design with the use of a mixed methods approach.