The ‘Pathways’ transformative knowledge network is an international group of research organisations, collaborating to explore processes of social transformation and to share insights across disciplines, cultures and contexts. Working across the domains of food, energy and water, the network is experimenting with new methods of research and engagement that both help to understand – and contribute to – transformations to sustainability. This article outlines some of the early experiences of two hubs in the network (UK and Argentina) and reflects on the lessons learned for ‘engaged excellence’. It also describes how approaches to transdisciplinary research (building on a diversity of academic and non-academic traditions) vary across different contexts, and how wider lessons in this regard will be shared across the consortium into the future.